Pain Medications

Best Pain Medications to use

Pain medicines, whether they’re over-the-counter or prescription-strength, can help you manage chronic pain and other kinds of pain. They’re powerful drugs, so it’s important to use them with care. It’s best to start with the safest drugs at the lowest effective dose for the shortest amount of time and work up from there as needed.

Be aware of possible side effects and interactions with other drugs and supplements you take. And always follow the directions on the label or your doctor’s prescription.

Over-the-Counter Pain Relievers

Over-the-counter (OTC) pain relievers include:

  • Acetaminophen (Tylenol)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, naproxen, and diclofenac gel

Both acetaminophen and NSAIDs reduce fever and relieve pain caused by muscle aches and stiffness, but only NSAIDs can also reduce inflammation (swelling, heat, redness related to an injury, and irritation). Acetaminophen and NSAIDs also work differently. NSAIDs relieve pain by reducing the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Acetaminophen works on the parts of the brain that receive the “pain messages.” NSAIDs are also available in a prescription-strength that can be prescribed by your doctor.

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